The transmembrane 4 superfamily (TM4SF) is a family of leukocyte surface glycoproteins that presumably cross the cell membrane four times.
These proteins may be involved in transmembrane signal transduction regulation of cell proliferation, differentiation and motility.
Members of this family, which include CD9, CD37, CD53, CD63, CD82 and TAPA-1, share significant sequence homology and an extracellular N-glycosylated domain, implicating these proteins as metastasis suppressors.
Only three members of this family have been correlated with metastasis: CD9, CD63 and CD82, also known as KAI 1.
KAI 1 is evolutionarily conserved and expressed in a broad range of human tissues, but exhibits reduced expression in human cell lines derived from metastatic prostate tumors.
It has been suggested that decreased KAI 1 expression may be involved in the malignant progression of prostate and perhaps other cancers.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of CD82. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant full length Human CD82.
Shelf Life：1year
Swiss Prot Number：P27701
EU Commodity Code：30021010
商品名：CD82 (4F9, Antigen detected by monoclonal and, IA4, C33, C33 Antigen, CD 82, CD82, Cd82, CD82 Antigen, CD82 Molecule, CD82_HUMAN, GR 15, GR15, IA 4, IA4, Inducible Membrane Protein, Inducible Membrane Protein R2, KAI 1, KAI1, Kangai 1 (suppression of Tumorigenicity 6, Prostate, CD82 Antigen (R2 leukocyte Antigen, Antigen detected by monoclonal and, IA4)), Kangai 1, Kangai1, Leukocyte Surface Antigen R2, Metastasis Suppressor Kangai 1, Metastasis Suppressor Kangai-1, Metastasis Suppressor Kangai1, Prostate Cancer antimetastasis Gene KAI1, R2, R2 leukocyte Antigen, SAR 2, SAR2, ST 6, ST6, Suppression of Tumorigenicity 6, Suppression of Tumorigenicity 6 Prostate, Suppressor of Tumorigenicity 6, Suppressor of Tumorigenicity 6 Protein, Tetraspanin 27, Tetraspanin-27, Tetraspanin27, Tspan 27, Tspan-27, Tspan27) 50ul
