84-2311-32　［取扱停止］CD32-C (CD32C, CDw32, Fc fragment of IgG low affinity IIc Receptor, Fc gamma RII c, Fc gamma RIIc, Fc-gamma RII-c, Fc-GAMMA-RIIC, FCGR2C, FcRII c, IgG Fc Receptor II c, Ly-17, Ly-m20, LyM-1, Lymphocyte Antigen 17, MGC23887, MGC30032) 100ul　221505

特徴

• CD32 (also designated FcγRII) is a low affinity receptor for the Fc fragment of aggregated IgG.
• CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of , production by B cells.
• IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells.
• CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B and C.
• These isoforms are designated FcγRIIA, FcγRIIB1, FcγRIIB3 and FcγRIIC.
• All isoforms are present on monocytes, placental trophoblasts and endothelial cells.
• In addition, the FcγRIIB forms are present on B lymphocytes, and the FcγRIIA and FcγRIIC forms are found on neutrophils.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.