CS1, also known as novel Ly9, SLAMF7, CD319, 19A24 or CRACC, is a homophilic cell surface receptor.
It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells.
CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein).
In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent.
CS1 recruits and associates with EAT-2, a protein closely related to SAP.
EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase.
In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of CD319. Species Crossreactivity: Human
