CDCP1 (CUB-domain-containing protein 1) contains three extracellular CUB domains, a transmembrane domain and two putative cytoplasmic tyrosine phosphorylation sites.
Phosphorylation of the gp140 and p80 proteins is mediated by Src family kinases at various tyrosine residues, including Tyr 734.
PTP family members mediate the desphosphorylation of CDCP1.
The conversion of gp140 to p80 prolongs the phosphorylation state, which may affect signaling in epithelial wounds.
CDCP1 acts as a marker for hematopoetic cells and also exhibits high expression in metastatic colon and breast tumors.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CD318, phosphorylated Y707. Species Crossreactivity: Human, mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic phosphopeptide derived from human CD318 around the phosphorylation site of Tyrosine 707.
