84-2309-67　［取扱停止］CCAR1 (Cell Division Cycle and Apoptosis Regulator Protein 1, Cell Cycle and Apoptosis Regulatory Protein 1, CARP-1, Death inducer with SAP Domain, CCAR1, CARP1, DIS) 50ul　221421

特徴

• CARP-1 (cell division cycle and apoptosis regulator 1), also known as CCAR1 or DIS, is a 1,150 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one SAP domain.
• Expressed in several epithelial cancer cell lines, including breast, colon, prostate and leukemia, CARP-1 is involved in apoptotic signaling, as well as in cell cycle progression and cell proliferation via interaction with c-Myc and cyclin B1.
• CARP-1 is subject to DNA damage-induced phosphorylation, probably by ATM or ATR.
• The gene encoding CARP-1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
• Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.