84-2309-57　［取扱停止］CBX4 (CBX 4, CBX4, Cbx4 chromobox Homolog 4 (Drosophila Pc class), CBX4_HUMAN, Chromobox Homolog 4 (Pc class Homolog, Drosophila), Chromobox Homolog 4, Chromobox Protein Homolog 4, E3 SUMO Protein Ligase CBX 4, E3 SUMO Protein Ligase CBX4, E3 SUMO-Protein Ligase CBX4, hPc 2, hPc2, NBP 16, NBP16, NS5ATP1 Binding Protein 16, Pc 2, Pc class 2 Homolog, Pc class Homolo ...　221415

特徴

• Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription.
• The PcG protein MPc2, also known as CBX4, PC2 or HPc2, maps to human chromosome 17q25.3.
• MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1.
• MPc2 is a repressor of proto-oncogene activity, thus interference with MPc2 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation.
• MPc2 is able to act as a long range transcriptional silencer.
• MPc2 is expressed in the human osteosarcoma cell line U-20S.
• MPc2 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.