The cannabinoid receptors (CB1 and CB2) are G-protein coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids.
CB1 is expressed in brain tissue and, in low levels, in testis.
Phosporylation of CB1 on serine 316 leads to a disruption of CB1-mediated inhibition of calcium channels and activation of potassium currents.
This response system is thought to be involved in specific brain functions, such as nociception, control of movement, memory, and neuroendocrine regulation as well as having a possible role in brain development.
In addition, CB1 may mediate the addictive behavior involved with the use of psychoactive cannabinoids, such as THC in marijuana.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CB1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 150-200 of Human CB1.
