The F-Actin family of capping proteins includes CapZ-alpha1, CapZ-alpha2, CapZ-alpha3 and CapZ-beta3, all of which function in a calcium-dependent manner and bind to the fast growing barbed end of Actin filaments, thereby blocking protein exchange at these ends.
The F-Actin capping protein complex is a heterodimer consisting of alpha and beta subunits that caps the barbed ends of Actin filaments and nucleates the polymerization of Actin monomers, yet does not sever Actin filaments.
CapZ-alpha1, also known as F-Actin-capping protein subunit alpha-1, is a 286 amino acid subunit of the heterodimer that forms the F-Actin capping protein complex.
CapZ-alpha1 also has been shown to bind S-100 beta chain, a signaling molecule involved in the calcium-sensitive assembly of intermediate filaments that has been linked to Alzheimer’s disease.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of CAPZA2. Species Crossreactivity: Human, mouse, rat
