84-2307-06　［取扱停止］CAPN1 (Ca2 Activated neutral Protease, Calcium Activated neutral Proteinase 1, Calcium Activated neutral Proteinase, Calcium Activated neutral Proteinase Small Subunit, Calcium Dependent Protease Small Subunit 1, Calcium Dependent Protease Small Subunit, Calcium-Activated neutral Proteinase 1, Calpain 1 (mu/I) large Subunit, Calpain 1, Calpain 1 Catalytic Subunit, ...　221287

特徴

• Calpain 1, also designated µ-calpain, is an intracellular calcium-dependent protease that cleaves cyto-skeletal and submembranous proteins.
• Calpains are nonlysosomal, calcium-activated intracellular cysteine proteases.
• Calpains mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis.
• Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94.
• Calpain-1 colocalizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain.
• Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.