Calcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms.
Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development.
Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome.
DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.
The gene encoding DSCR 1 maps to human chromosome 21, which which houses ~300 genes and comprises nearly 1.5% of the human genome.
Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of Calcipressin-1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to the 207-252 of Human Calcipressin-1.
