Voltage-dependent Ca2+ channelsmediate Ca2+ entryinto excitable cells in response tomembrane depolarization, and they are involved in a variety of Ca2+-dependent processes, includingmuscle contraction, hormone or neurotransmitter release and gene expression.
Calciumchannels are highly diverse, multimeric complexescomposed of analpha-1 subunit, an intracellular beta-subunit, a disulfide linkedalpha-2/delta-subunit and a transmembrane y-subunit.
Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R-types.
R-type Ca++ currentsinitiate a rapid synaptictransmission that isregulated through G proteins, SNARE proteins, and protein phosphorylation.
R-type Ca++ channels may partially regulate the secretory processin chromaffin cells bymediating rapid secretoryresponses evoked byshort depolarizing pulses.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CACNA1E. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human CACNA1E.
