The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation.
Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis.
C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathways of the serum complement system.
C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio.
C1r is a dimer formed of two identical chains that are activated by cleavage into two chains, A and B.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of C1r. Species Crossreactivity: Human, mouse, rat
