C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA.
Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10).
This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3’-5’ rRNA processing.
Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbalpha (V-erbA-related protein EAR-1)/TRbeta (thyroid hormone receptor beta) and p53, respectively.
C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of C1D. Species Crossreactivity: Human, mouse, rat
