84-2305-57　［取扱停止］C19orf10 (C19orf10, Chromosome 19 Open Reading Frame 10, CS010, EUROIMAGE1875335, IL 25, IL 27, IL-25, IL25, IL27, IL27w, Interleukin 25, Interleukin 27 working designation, Interleukin-25, Interleukin25, R33729 1, R337291, SF20, Stromal Cell derived Growth Factor, Stromal Cell derived Growth Factor SF20, Stromal Cell-derived Growth Factor SF20, Uncharacterized Pr ...　221212

特徴

• The interleukins are a broad family of well characterized cytokines, primarily of hematopoietic cell origin.
• Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types.
• Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response (1,2).
• IL-25 (also called SF20/IL-25) is a secreted bone marrow stroma-derived growth factor cytokine that is derived from Th2 T-cells (3,4).
• IL-25 belongs to the IL-17 cytokine family and is capable of amplifying allergic type inflammatory responses by its actions on other cell types (4,5).
• IL-25 binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation (3).
• Infusion of mice with IL-25 induces IL-4, IL-5, and IL-13 gene expression (4,5).
• IL-25 induced mice also develop epithelial cell hyperplasia, increased mucus secretion, and airway hyperreactivity (4,5), suggesting that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13 and eotaxin (5).
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.