84-2305-53　［取扱停止］C11orf30 (C11orf30, Chromosome 11 Open Reading Frame 30, EMSY Protein, FLJ90741, GL002, Protein EMSY) 50ul　221210

特徴

• EMSY interacts with BRCA2 and plays a role in chromatin remodeling.
• This interaction has been confirmed in HeLa cells.
• Overexpression of EMSY strongly correlates with amplification in sporadic breast cancer and higher grade ovarian cancer.
• The EMSY gene is amplified in 18% of breast cancer cell lines.
• EMSY amplification is highly correlated with DNA amplification in both cell lines and primary tumors.
• This amplification is a general sign of poor prognosis and shortened disease-free survival time.
• EMSY from a wide variety of species has a conserved 80 amino acid sequence at the N-terminus.
• In irradiated MEFs (mouse embryonic fibroblasts), EMSY was found to migrate to damaged DNA.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.