C/EBP family members include C/EBP alpha, C/EBP beta, C/EBP y, C/EBP delta, C/EBP ε and C/EBP zeta, all of which are capable of forming homodimers or heterodimers with each other.
C/EBP zeta, also known as CBF2, NOC1, CHOP10 (C/EBP homologous protein 10), GADD153 (growth arrest and DNA damage-inducible gene 153) or HSPCBF, is a ubiquitously expressed 1,054 amino acid protein that localizes to the nucleus and regulates transcription.
More specifically, C/EBP zeta is believed to play a role regulating the expression of CRP (C-reactive protein).
Unlike most C/EBP dimers, C/EBP zeta-containing dimers do not bind the classical C/EBP-binding consensus sequence.
Rather, C/EBP zeta-containing dimers must associate with RBP-Jκ (another transcription factor) in order to accomplish binding to the C/EBP site.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of C/EBP. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminus of Human C/EBP ζ.
