BST-1 (bone marow stromal antigen-1) has been identified as a surface molecule that is GPI-anchored to the cell membrane of stromal cells.
Both ADP-ribosyl cyclase and cADPR hydrolase activites have been demonstrated by BST-1.
cADPR activity is a potential regulator of insulin secretion in pancreatic beta cells.
Most pancreatic islet cells express BST-1, indicating a link between BST-1 and insulin secretion.
BST-1 expression has also been found in a wide range of tissues including umbilical vein endothelial cells, monocytes and granulocytes.
BST-1 expression in thymus tissue and on B and T cell progenitors undergoing gene rearrangement implicates BST-1 as a useful marker for lymphoid progenitor cells that are initiating gene rearrangement of their antigen receptors.
BST-1 has also been shown to facilitate B cell growth and may act as a receptor.
Applications:Suitable for use in Western Blot, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of BST1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 120-165 of Human BST1.
