Breast cancer metastasis-suppressor 1 (BRMS1) acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary.
BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta.
BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes.
BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex.
The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression.
This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue.
BRMS1 is stabilized by Hsp90 and may inhibit NFκB activity.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of BRMS-1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 210-58 of Human BRMS-1.
