The breast cancer-associated antigen BRCAA1, also designated ARID domaincontaining protein 4B (ARID4B), Sin3-associated polypeptide p180 (SAP180),or Retinoblastoma-binding protein 1-like 1 (RBBP1L1 or RBP1L1), shares 37% amino acid identity and an identical antigen epitope, SSKKQKRSHK, with Rb binding protein 1.
High expression of BRCAA1 mRNA has been found in human breast, lung, colon, pancreatic and ovarian cancers, as well as in normal testis.
This expression pattern indicates that BRCAA1 can be uses as a molecular marker for a broad range of human malignancies.
BRCAA1 also interacts with RBBP1/ARID4A and regulates genomic imprinting at the Prader-WIlli syndrome (PWS)/Angelman syndrome (AS) domain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of BRCAA1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 776-832 of Human BRCAA1.
