84-2303-25　［取扱停止］Bradykinin B1 (B1 bradykinin Receptor, B1R, BK-1 Receptor, BRADYB1, BDKRB1) 50ul　221093

特徴

• Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception.
• Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide.
• Bradykinin normally exerts its effects through the activation of two seven transmembrane G protein-coupled receptors, named B1 and B2.
• The B2 receptor has an apparent molecular mass of 75-80kDa (as observed in SDS-PAGE), is constitutively expressedand preferentially binds full length bradykinin.
• Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice.
• The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively.
• The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines.
• The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.
• Applications:Suitable for use in Immunofluorescence, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.