84-2303-07　［取扱停止］BMPR2 (Bone morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1) 50ul　221084

特徴

• Members of the transforming growth factor beta superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex.
• Two type I receptors have been characterized, BMPR-IA (also designated SKR5, ALK-3, and BRK-1) and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7).
• BMPR-IA and BMPR-IB are both expressed in human glioma cell lines.
• The type II receptor, BMPR-II, efficiently binds to OP-1 and BMP-2 and weakly binds BMP-4, and it is widely expressed in different tissues, including brain.
• The BMP receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.