Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation.
Bcl-7c (B-cell CLL/lymphoma 7 protein family member C) is a 217 amino acid anti-apoptotic protein that shares 90% sequence similarity to Bcl-7a.
Knockdown of IL-10 mRNA induces apoptosis and leads to significant down-regulation of Bcl-7c, suggesting that a modulatory relationship exists between the two proteins.
The gene encoding Bcl-7c maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn’s disease, which is a gastrointestinal inflammatory condition.
There are two isoforms of Bcl-7c that are produced as a result of alternative splicing events.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of BCL7C. Species Crossreactivity: Human
