84-2302-20　［取扱停止］BCL2A1 (Bcl-2-Related Protein A1, Bcl-2-like Protein 5, Bcl2-L-5, Hemopoietic-specific early Response Protein, Protein BFL-1, Protein GRS, BCL2A1, BCL2L5, BFL1, GRS, HBPA1) 50ul　221035

特徴

• The Bcl-2 family of proteins is characterized by its ability to modulate cell death under a broad range of physiological conditions.
• Bcl-2 and Bcl-xL function to inhibit apoptosis while other members of the Bcl-2 family, Bax, Bad, Bak and Bcl-xS, oppose death-suppressing effects .
• An additional member of the family, A1 (also designated Bfl-1), dimerizes with both Bcl-2 and Bax and has been identified as a hematopoietic-specific, early inducible gene .
• While A1 demonstrates life promoting properties similar to those of Bcl-2, its function may be more temporally regulated during myeloid differentiation and dependent on additional growth stimuli to confer its life promoting properties.
• A1 is abundantly expressed in bone marrow and at low levels in other tissues.
• There is evidence that a correlation exists between a high expression of the A1 gene product and stomach cancer.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.