Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity.
It hydrolyzes acylcholine into choline and carboxylate.
BChE is synthesized in the liver and is highly reactive with organophosphate esters.
BChE can form a homotetramer composed of two dimers linked by a disulfide bond.
Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia.
Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function.
In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters.
This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of BCHE. Species Crossreactivity: Human, mouse, rat
