84-2301-53　［取扱停止］BAIAP2 (BAI Associated Protein 2, BAI-Associated Protein 2, BAI1 Associated Protein 2, BAI1-Associated Protein 2, BAIAP 2, Baiap2, BAIP2_HUMAN, BAP2, Brain specific angiogenesis Inhibitor 1 Associated Protein 2, Brain-specific angiogenesis Inhibitor 1-Associated Protein 2, Fas Ligand Associated Factor 3, Fas Ligand-Associated Factor 3, FLAF3, Insulin Receptor Subs ...　221002

特徴

• The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the Actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases.
• It is expressed in the cytoplasm and links small membrane-bound G-proteins to cytoplasmic effector proteins.
• IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of Actin regulators, and a conserved N-terminal IRSp53/MIM homology domain (IMD) that harbors F-Actin-bundling activity.
• IRSp53 inter-acts with atrophin-1, the product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene, which is associated with an autosomal dominant neurodegenerative disease.
• The IRSp53 protein also interacts with ENAH, BAI-1, Eps8, Shank 1, Shank 2, Shank 3, WAVE1, WAVE2, Tiam1 and Dia 1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.