84-2301-06　［取扱停止］B2M (B2MG, Beta 2 microglobin, Beta 2 microglobulin, Beta 2 microglobulin Precursor, Beta Chain of mhc class 1 Proteins, Beta Chain of MHC class I Molecules, Beta-2-microglobulin form pI 5.3) 100ul　220978

特徴

• Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells.
• The proteasome is responsible for producing these antigens from the components of foreign pathogens.
• MHC class 1 molecules consist of an a heavy chain that contains three subdomains (alpha1, alpha2, alpha3), and a non-covalent associating light chain, known as beta-2-Microglobulin.
• beta-2-Microglobulin associates with the a3 subdomain of the a heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules.
• The alpha1 and alpha2 domains of the a heavy chain form the peptide antigen-binding cleft.
• Mice that lack beta-2-Microglobulin protein show a normal distribution of T cells, yet have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated cytotoxicity.
• Interferon-y can stimulate production of beta-2-Microglobulin transcripts.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.