84-2300-30　［取扱停止］ATP2C1 (ATP Dependent Ca(2+) pump PMR1, ATP-Dependent Ca(2+) pump PMR1, ATP2C1, ATP2C1A, ATPase 2C1, ATPase Ca(2+) sequestering, ATPase Ca++ transporting Type 2C Member 1, AW061228, BCPM, Calcium transporting ATPase Type 2C Member 1, Calcium-transporting ATPase Type 2C Member 1, D930003G21Rik, HHD, hSPCA1, HUSSY 28, KIAA1347, PMR1, PMR1, rat, Homolog of, PMR1L, Se ...　220940

特徴

• The Saccharomyces cerevisiae protein, PMR1, encodes P-type calcium transport ATPase, which localizes to the Golgi and regulates the intracellular transport of calcium and manganese.
• The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA).
• PMR1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids.
• PMR1 is mutated in Hailey-Hailey disease (HHD), which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin.
• These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.