84-2300-13　［取扱停止］ATM, phosphorylated (S1981) (A-T mutated, A-T mutated Homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT Protein, AT1, AT1, ATA, Ataxia telangiectasia Gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated Gene, Ataxia telangiectasia mutated Hom ...　220930

特徴

• The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups.
• The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases.
• The PIK-related kinases include Atm, DNA-PKCS and FRAP.
• These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases.
• The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes.
• AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.