Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males.
The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors.
ARs bind active testosterone (T) and dihydrotestosterone (DHT).
The rates of association and dissociation of T are about 3 times more rapid than those of DHT.
This difference in binding kinetics may account for the different physiological effects of T and DHT.
Androgen binding results in an at least 6-fold increase in androgen receptor stability.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of AR. Species Crossreactivity: Human, mouse, rat
