A proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family.
APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues.
APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis.
APRIL is implicated in the regulation of tumor cell growth.
The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization.
The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events.
Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of APRIL. Species Crossreactivity: Human, mouse, rat
