Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets.
Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease.
The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms.
Proteolytic cleavage of APP leads to the formation of the Amyloid beta/A4 Amyloid protein.
This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients.
APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:1000Immunohistochemistry (Paraffin): 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, pH 7.2, 0.05% sodium azide
Specificity：Recognizes endogenous levels of human APP/beta. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 701-750 of human APP/beta-Amyloid. UniProt Accession: P05067.
Shelf Life：1year
Swiss Prot Number：P05067
EU Commodity Code：30021010
商品名：APP/beta (Amyloid beta A4 Protein, ABPP, APPI, Short name=APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-Amyloid Protein 42, Beta-APP42, Beta-Amyloid Protein 40, Beta-APP40, P3(42), P3(40), Gamma-Secretase C-Terminal fragment 59, Amyloid intracellular Domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-Secretase C-Terminal fragment 57, Amyloid intracellular Domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-Secretase C-Terminal fragment 50, Amyloid intracellular Domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-beta, Amyloid beta, Amyloidbeta, beta Amyloid, betaAmyloid, Abeta) 100ul
