Apolipoproteins are protein components of plasma lipoproteins.
ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins.
ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes.
Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel beta barrel which binds retinol and retinoic acid.
ApoM may play a key role in reverse cholesterol transport.
It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL).
ApoM is important for the prebeta-HDL formation.
Prebeta-HDL is an important acceptor of peripheral cellular cholesterol.
The concentration of ApoM in plasma strongly correlates with total cholesterol.
Low concentrations of ApoM in plasma is associated with diabetes.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human APOM. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Full-length recombinant protein of human APOM.
