84-2296-87　［取扱停止］APBB1 (Adaptor Protein FE65a2, Amyloid beta (A4) Precursor Protein Binding Family B Member 1, Amyloid Beta A4 Precursor Protein Binding Family B, Amyloid beta A4 Precursor Protein Binding Family B Member 1, Amyloid beta A4 Precursor Protein-Binding Family B Member 1, Amyloid beta Precursor Protein Binding Family B Member 1, APBB 1, APBB1, APBB1_HUMAN, FE 65, Fe65 ...　220767

特徴

• The protein encoded by this gene is a member of the Fe65 protein family.
• It is an adaptor protein localized in the nucleus.
• It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein.
• APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation.
• This encoded protein could play an important role in the pathogenesis of Alzheimer's disease.
• It is thought to regulate transcription.
• Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
• Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.