84-2296-79　［取扱停止］AP2B1 (Adapter Related Protein Complex 2 beta 1 Subunit, Adapter-Related Protein Complex 2 beta Subunit, Adaptin, beta 2 (beta), Adaptor Protein Complex AP-2 Subunit beta, Adaptor Related Protein Complex 2, beta 1 Subunit, ADTB2, AP-2 Complex Subunit beta, AP105B, AP2 BETA, Ap2b1, AP2B1_HUMAN, Beta adaptin, Beta-2-adaptin, Beta-adaptin, Beta2 adaptin, CLAPB1, Clat ...　220763

特徴

• Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with clathrin associated protein complexes.
• Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex.
• The AP-1 and AP-2 adapter protein complexes consist of clathrin binding adaptin proteins (g and b1 for AP-1, a and b2 for AP-2) and two smaller subunits known as AP50 and AP17.
• The alpha and beta adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length.
• a-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues.
• AP180 (also designated AP-3 or F1-20) is a synapse-specific clathrin assembly protein.
• The protein CALM (clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in clathrin assembly.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.