84-2296-63 ［取扱停止］ANP32A (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A, Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein pp32, AN32A_HUMAN, ANP32A, C15orf1, Cerebellar Leucine Rich Acidic Nuclear Protein, Hepatopoietin Cn, HPPCn, I1PP2A, Inhibitor 1 of Protein Phosphata ... 220755
84-2296-63 ［取扱停止］ANP32A (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A, Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein pp32, AN32A_HUMAN, ANP32A, C15orf1, Cerebellar Leucine Rich Acidic Nuclear Protein, Hepatopoietin Cn, HPPCn, I1PP2A, Inhibitor 1 of Protein Phosphata ... 220755
Protein phosphatase 2A PP2A is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes.
ANP32A, also known as Inhibitor 1 of PP2A (I1PP2A), and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A.
ANP32A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II.
These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C.
The ANP32A protein is localized to both the cytoplasm and the nucleus.
In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms’ tumor cells.
Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of ANP32A. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human ANP32A.
Shelf Life：1year
Swiss Prot Number：P39687
EU Commodity Code：30021010
商品名：ANP32A (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A, Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein 32 Family Member A, Acidic Nuclear Phosphoprotein pp32, AN32A_HUMAN, ANP32A, C15orf1, Cerebellar Leucine Rich Acidic Nuclear Protein, Hepatopoietin Cn, HPPCn, I1PP2A, Inhibitor 1 of Protein Phosphatase 2A, Inhibitor-1 of Protein Phosphatase-2A, Lanp, Leucine Rich Acidic Nuclear Protein, Leucine-Rich Acidic Nuclear Protein, MAPM, Mapmodulin, MGC119787, MGC150373, PHAPI, Potent Heat stable Protein Phosphatase 2A Inhibitor I1PP2A, Potent Heat-stable Protein Phosphatase 2A Inhibitor I1PP2A, PP32, Putative HLA DR Associated Protein I, Putative HLA-DR-Associated Protein I, Putative Human HLA Class II Associated Protein, Putative human HLA class II Associated Protein I, Putative human HLA class II-Associated Protein) 100ul
