84-2295-82　［取扱停止］AMPH (Amp, AMPH 1, AMPH, AMPH_HUMAN, AMPH1, Amphiphysin (Stiff-Man Syndrome with breast Cancer 128kD Autoantigen), Amphiphysin (Stiff-Man Syndrome with breast Cancer 128kDa Autoantigen), Amphiphysin, Amphiphysin I, CG8604, Damp, dAmph, Dmel￥CG8604, HGNC:471, MGC49429, Stiff man Syndrome with breast Cancer 128kD Autoantigen, Stiff man Syndrome with breast Cancer 128kDa Autoantigen) 100ul　220714

特徴

• Amphiphysin is a brain-enriched protein that exhibits N-terminal lipid interaction and functions as a dimer.
• Amphiphysin contains a membrane bending BAR domain, a middle Clathrin and adaptor binding domain, and a C-terminal SH3 domain.
• In the brain, Amphiphysin I and II form heterodimers that bind to the Clathrin associated GTPase Dynamin via their SH3 domains.
• This association is essential for synaptic vesicle recycling in neurons, as it precedes the binding of Dynamin to the Clathrin-coated pits and the subsequent vesicle budding.
• In other tissues, Amphiphysin may play a key role in other membrane bending and curvature stabilization events.
• The mammalian Amphiphysins, Amphiphysin I and Amphiphysin II, have similar overall structure.
• A ubiquitous splice form of Amphiphysin II that does not contain Clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T tubule network.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.