Dental enamel is a highly mineralized tissue with most of its volume occupied by large, highly organized, hydroxyapatite crystals.
This structure is thought to be controlled through the interaction of many organic matrix molecules including Amelogenin, Ameloblastin, Enamelin, Tuftelin and several other enzymes.
All of these secreted proteins are involved in the mineralization and enamel matrix formation in developing tooth enamel.
Ameloblastin (AMBN), which localizes to the extracellular matrix, is an ameloblast-specific protein.
It is detected in the sheath space between rod-interrod enamel and at the Tomes processes of secretory ameloblasts.
Defects in the gene encoding for ameloblastin, AMBN, can be seen in patients with ameloblastomas.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Ameloblastin. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to amino acids 300-345 of Human Ameloblastin.
