Fused toes protein homolog (FTS), also known as AKT-interacting protein (AKTIP) and Ft1, is a 292 amino acid protein that localizes to the cytoplasm and the cell membrane.
A member of the ubiquitin-conjugating enzyme family, FTS binds directly to AKT1 to regulate apoptosis in a cell population.
AKT1 is a protein that plays a critical role in a number of cellular responses, such as cell growth, protein synthesis, and antiapoptotic signaling.
The interaction of FTS and AKT1 enhances the phosphorylation and activation of AKT1, which, through an AKT1/GSK-3beta/NFATc1 signaling cascade, results in the increased production of the proapoptotic hormone Fas ligand and thus an increase in apoptosis.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of AKTIP. Species Crossreactivity: Human, mouse, rat
