Fetuin (also designated a-2-z-globulin or a-2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/ macrophages and in bone and is down-regulated during injury and inflammation.
Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules.
Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury.
During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages.
This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macrophage, which in turn facilitates macrophage-deactivating mechanisms.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of AHSG. Species Crossreactivity: Human
