HIV-1 Rev is the prototype of a class of retroviral regulatory proteins that control the sequence-specific nuclear export and translation of a class of incompletely spliced HIV-1 mRNAs that encode viral structural proteins.
In the absence of Rev, these late viral RNAs remain sequestered in the nucleus until they are either spliced or degraded.
The protein designated Rev interacting protein (RIP) or Rev/Rex activation domain-binding protein (Rab) contains 562 amino acids.
RIP/Rab has been identified as a cellular cofactor that binds not only to the HIV-1 Rev activation domain, but also to equivalent domains of other Rev and Rex proteins.
On the basis of these findings it has been speculated that RIP/Rab is required for the Rev response and thus for HIV-1 replication.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of AGFG1. Species Crossreactivity: Human, mouse, rat
