ADH7 (alcohol dehydrogenase 7 (class IV), µ or sigma polypeptide), is a 386 amino acid protein belonging to the zinc-containing alcohol dehydrogenase family and the class-IV subfamily.
Seven different human ADH isozymes exist: three belong to class-I: alpha, beta and y; one to class-II: π; one to class-III: χ; one to class-IV: ADH7; and one to class-V: ADH6.
Encoded by a gene that maps to human chromosome 4q23, ADH7 localizes to the cytoplasm and is preferentially expressed in stomach, but, unlike other family members, is absent from liver.
ADH7 is a homodimer that binds two zinc ions per subunit and contains nine exons.
ADH7 participates in the synthesis of retinoic acid, a hormone important for cellular differentiation.
Variations in ADH7 may be associated with alcohol dependence.
ADH7 may also play a role in protection against aerodigestive tract cancer.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of ADH7. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human ADH7.
