84-2293-33　［取扱停止］ADAM23 (Disintegrin and Metalloproteinase Domain-Containing Protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-Rich Protein 3, MDC-3, ADAM-23, MDC3) 50ul　220586

特徴

• ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins that are expressed in numerous different tissues.
• They catalyze proteolysis, adhesion, fusion and intracellular signaling.
• ADAMs are membrane-anchored proteins, and there are over 30 different members in the family with many diverse functions.
• ADAM 23 is exclusively expressed in fetal and adult brain and may function as an integrin ligand in cells of neural origin.
• Adhesion of neuroblastoma and astrocytoma cells is promoted by the disentegrin-like domain of ADAM23 and is mediated by an interaction of this protein with åvbeta3.
• A short amino acid sequence in the disintegrin loop of ADAM23 interacts with åvbeta3 to mediate cell interactions that take place during both normal and pathological processes.
• The three characteristic histidine residues and the glutamic acid residue typical of metalloproteinases are lacking in the metalloproteinase-like domain of ADAM23.
• This suggests that ADAM23 may not be involved in protease-mediated events, but could exclusively serve in cell adhesion processes.
• In addition, evidence suggests that ADAM23 may be a tumor suppressor gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.