Human prostatic acid phosphatase (also known as PAcP, PAP, PPAP, ACPP) is a prostate epithelium-specific differentiation antigen.
The cellular form of PAcP functions as a neutral protein-tyrosine phosphatase, and is involved in regulating prostate cell growth.
Specifically, PAcP catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate.
PAcP is synthesized under androgen regulation.
The stimulated secretion of prostatic acid phosphatase is a hallmark of androgen action on human prostate epithelial cells, implicating PAcP as a useful tool in identifying atrophy of prostatic tissue.
Cellular PAcP can down-regulate prostate cancer cell growth, at least partially by dephosphorylating c-ErbB-2/neu.
Therefore, decreased cellular PAcP expression in cancer cells may be involved in prostate cancer progression.
PAcP is the protein product of the human ACPP gene, which maps to chromosome 3q21-q23.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of ACPP. Species Crossreactivity: Human, mouse, rat
