The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane.
All four proteins are ABC half-transporters, which dimerize to form an active transporter.
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage.
ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD.
The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3.
ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors.
ABCD1 localizes to peroxisomes.
ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of ABCD4. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 157-202 of Human ABCD4.
