Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.
Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively.
SNCA may serve to integrate presynaptic signaling and membrane trafficking.
Defects in SNCA have been implicated in the pathogenesis of Parkinson disease.
SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.
Two alternatively spliced transcripts of SNCA have been identified.
Additional splicing may be present but the full-length nature of these variants has not been determined.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Specificity：Recognizes rat alpha synuclein, phosphorylated at Serine 129.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to amino acids surrounding the phosphoSerine 129 site of rat alpha synuclein. Species sequence homology: human, mouse, non-human primate, bovine and canine (100%).
