84-2269-09　Rgs4 (Regulator of G-protein Signaling 4, RGP4, RGS4) 100ul　217742

特徴

• Regulator of G-protein signaling 4 (RGS4) is a GTPase activating protein belonging to the RGS family.
• This is a group of proteins known to act as GTPase activating proteins (GAPs), in order to regulate G protein signaling.
• RGS4 is highly expressed throughout the brain with highest expression observed in the prefrontal cortex, and some expression found in peripheral tissues such as the heart.
• RGS4 acts as a signal transduction inhibitor by inactivating G protein alpha subunits through the increase of their GTPase activity.
• Also, RGS4 serves to enhance Gi/o and Gq/11 protein GTPase activity and to expedite the conclusion of GPCR signaling.
• Various studies indicate a potential role for RGS4 in the regulation of various neurotransmitter systems, including those with putative involvement in schizophrenia.
• Mutations in the RGS4 gene lead to a lower presence of RGS4, linked to both Schizophrenia and Alzheimer's symptoms.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000 detected RGS4 in 10ug of PC12 cell lysate
• Optimal dilutions to be determined by the researcher.
• Control:PC12 cell lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.