Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.
May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults.
Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Applications:Suitable for use in Neutralization of VEGF-C induced VEGFR3.
Other applications have not been tested.
Recommended Dilutions:Neutralization: Mouse skin endothelial cells (SENDs) were treated with or without rat VEGF-C (50ng/ml) in the absence or presence of 5 or 20ug/ml antibody 217081 for 30 minutess and the phospho-VEGFR3 was detected with IP-Western for pTyrosine.
The conditions described here are for reference only.
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile PBS.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a lyophilized powder from PBS. Reconstitute with sterile PBS.
Specificity：Recognizes rat VEGF-C. Species Crossreactivity: human and mouse
Isotype：IgG
Calc Applications Abbrev：N
Calc Crossreactivity：Hu Mo Rt
Immunogen：Full length protein corresponding to rat VEGF-C.
