This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK).
HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system.
Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK.
In contrast to HMWK, LMWK is not involved in blood coagulation.
Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry(Paraffin): 7.5ug/mlImmunocytochemistry: 1:100-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.0, 0.01% Thimerosal, 40% glycerol.
Specificity：Recognizes human Kininogen.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein fragment corresponding to aa1-416 from human Kininogen.
