Contactins mediate cell surface interactions during nervous system development.
Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1.
Participates in oligodendrocytes generation by acting as a ligand of NOTCH1.
Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus.
Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth By similarity.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.3-1ug/mlImmunohistochemistry(Paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human CNTN1. Is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1. Species Crossreactivity: Gibbon, Chimpanzee, Guinea pig, Monkey, Mouse, Pig, Rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Gp Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to aa313-324, C-ENIRGKDKHQAR from an internal region of human Contactin 1 (NP_001834.2, NP_778203.1, NP_001242992.1).
