NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons.
NT3 is closely related to both NGF and BDNF.
It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta.
NT3-deficient mice generated by gene targeting display severe movement defects of the limbs.
The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Belongs to the NGF-beta family.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Antigen retrieval by boiling the paraffin/formalin section in 10mM citrate buffer, pH 6.0 for 20 minutes is recommendedOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from 5% BSApH 7.4, 0.9% sodium chloride, 0.2% Na2HPO4, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
Specificity：Recognizes human NT3. Tissue Specificity: Brain and peripheral tissues. Species Crossreactivity: mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to TVLGEIKTGNSPVKQY aa174-189, , from human NT3. Cellular Localization: Secreted protein.
